WIZ degrader 8, CAS 2879251-26-8

Product Description: WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1].

Formula: C21H27N3O4

References: [1]Kerrigan JR, et al. Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease. J Med Chem. 2024 Nov 28;67(22):20682-20694.

CAS Number: 2879251-26-8

Molecular Weight: 385.46

Research Area: Cardiovascular Disease

Target: Histone Acetyltransferase;Molecular Glues

• SKU: MEXHY-169955-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169955-5
• Package Unit: 5 mg
• Quantity Unit: STK