XE991, CAS 122955-42-4

Product Description: XE 991, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].

Applications: Neuroscience-Neuromodulation

Formula: C26H20N2O

References: [1]Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3./[2]Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

CAS Number: 122955-42-4

Molecular Weight: 376.45

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Potassium Channel

• SKU: MEXHY-108577A-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108577A-25
• Package Unit: 25 mg
• Quantity Unit: STK