XMD8-92, CAS 1234480-50-2

XMD8-92, CAS 1234480-50-2
SKU
MEXHY-14443-25
Packaging Unit
25 mg
Manufacturer
MedChemExpress

Availability: loading...
Price is loading...
Product Description: XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity[1][2].

Applications: Cancer-Kinase/protease

Formula: C26H30N6O3

References: [1]Yang Q, et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.Cancer Cell. 2010 Sep 14;18(3):258-67./[2]Yang Q, et al. Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res. 2011 Jun 1;17(11):3527-32./[3]Umapathy G, et al. The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. Sci Signal. 2014 Oct 28;7(349):ra102./[4]Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016;113(42):11865-11870.

CAS Number: 1234480-50-2

Molecular Weight: 474.55

Compound Purity: 99.48

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;ERK
More Information
SKU MEXHY-14443-25
Manufacturer MedChemExpress
Manufacturer SKU HY-14443-25
Package Unit 25 mg
Quantity Unit STK
Product information (PDF)
×
MSDS (PDF)
×