Yck2-IN-1, CAS 401816-26-0

Product Description: Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1].

Formula: C19H11FN4

References: [1]Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16(1):2156.

CAS Number: 401816-26-0

Molecular Weight: 314.32

Research Area: Infection

Target: Casein Kinase;Fungal

• SKU: MEXHY-168998-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168998-0
• Package Unit: Get quote
• Quantity Unit: STK