YJ9069

Product Description: YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC50 of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. (Pink: CDK12/CDK13 degradation agent (HY-168658); Black: Linker (HY-W015967); Blue: ligand for E3 ligase (HY-103596))[1].

Applications: Cancer-Kinase/protease

Formula: C46H46N10O7

References: [1]Yu Chang, et al. Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition. Cell Rep Med. 2024 Oct 15;5(10):101752.

Molecular Weight: 850.92

Compound Purity: 97.63

Research Area: Cancer

Solubility: DMSO : ≥ 50 mg/mL

Target: CDK;DNA/RNA Synthesis;PROTACs

• SKU: MEXHY-168556-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168556-10
• Package Unit: 10 mg
• Quantity Unit: STK