Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione
Purity: ≥95%
Formula Markup: C25H23ClF4N4O3
Formula Weight: 538.9
CAS Number: 1587727-31-8
Notes: PF-06648671 is a γ-secretase modulator.{72504} It selectively inhibits the production of amyloid-β (1-42) (Aβ42) in CHO cells expressing wild-type amyloid precursor protein (APP; IC50 = 9.8 nM) over Notch cleavage to its signaling effector Notch intracellular domain (NICD; IC50 = >15.8 µM). PF-06648671 (10 and 40 mg/kg) decreases brain levels of Aβ42 in rats. It also decreases cerebrospinal fluid (CSF) levels of Aβ40 and Aβ42 and increases levels of Aβ38 and Aβ39, without affecting total Aβ CSF levels, in dogs when administered at a dose of 20 mg/kg.
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