Pro-GA, CAS 2222067-12-9

Shelf life (days): 1460.0

Formulation: A powder

Formal Name: 5-[[(1S)-2-[(acetyloxy)methoxy]-1-methyl-2-oxoethyl]amino]-5-oxo-pentanoic acid, methyl ester

Purity: ≥95%

Formula Markup: C12H19NO7

Formula Weight: 289.2818

CAS Number: 2222067-12-9

Notes: A prodrug form of N-glutaryl-L-alanine and a GGCT inhibitor; reduces the viability of UM-UC-3 and T24 cells (IC50s = 58.5 and 57 µM, respectively) and RT-112 cells, which have a high expression of GGCT (IC50 = 73.9 µM); enhances mitomycin C-induced growth of RT-112 cells; inhibits the proliferation of MCF-7 breast cancer cells at 50, 75, and 100 µM; increases ROS production and induces senescence in MCF-7 cells, effects that can be blocked by NAC; reduces tumor weight in an MCF-7 mouse xenograft model at 25 mg/kg

• SKU: CAY42353-2
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42353-2
• Package Unit: 2 mg
• Quantity Unit: STK