ALK-IN-31, CAS 3043840-25-8

Product Description: ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC)[1].

Applications: Cancer-Kinase/protease

Formula: C30H33N5O2S

References: [1]Wang R, et al. Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research. Bioorg Chem. 2025 Jun 15;160:108416.

CAS Number: 3043840-25-8

Molecular Weight: 527.68

Research Area: Cancer

Target: Akt;Anaplastic lymphoma kinase (ALK);Apoptosis;mTOR

• SKU: MEXHY-173493-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173493-0
• Package Unit: Get quote
• Quantity Unit: STK