Product Description: Avitriptan is a 5-HT1B/1D receptor agonist, with pKis of 7.44 ( 5-HT1B rat), 7.68 ( 5-HT1B human) and 8.36 ( 5-HT1D human). Avitriptan constricts the isolated coronary artery. Avitriptan can be used for migraines[1].
Formula: C22H30N6O3S
References: [1]Saxena PR, et al. Effects of avitriptan, a new 5-HT 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential. Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):295-302.
CAS Number: 151140-96-4
Molecular Weight: 458.58
Research Area: Neurological Disease; Cardiovascular Disease
Target: 5-HT Receptor