Bosutinib (hydrate), CAS 918639-08-4

Product Description: Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively[1].

Applications: Cancer-Kinase/protease

Formula: C26H31Cl2N5O4

References: [1]Jorge E Cortes, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012 Oct 1;30(28):3486-92./[2]Miriam Puttini, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1;66(23):11314-22.

CAS Number: 918639-08-4

Molecular Weight: 548.46

Compound Purity: 99.97

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Bcr-Abl;Src

• SKU: MEXHY-10158A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10158A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK