CHPG, CAS 170846-74-9

Product Description: CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].

Applications: COVID-19-immunoregulation

Formula: C8H8ClNO3

References: [1]Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52./[2]Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.

CAS Number: 170846-74-9

Molecular Weight: 201.609

Compound Purity: 99.51

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: 1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 11 with NaOH)/DMSO : 25 mg/mL (ultrasonic;warming;adjust pH to 2 with 1 M HCl;heat to 60°C)

Target: Akt;ERK;mGluR;NF-κB

• SKU: MEXHY-101364-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101364-25
• Package Unit: 25 mg
• Quantity Unit: STK