Product Description: Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less potent with PGHS-1 (IC50=20 μM).
Applications: COVID-19-immunoregulation
Formula: C18H24N2O2S
References: [1]Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45./[2]Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85.
CAS Number: 139226-28-1
Molecular Weight: 332.46
Compound Purity: 99.49
Research Area: Inflammation/Immunology; Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Leukotriene Receptor;Prostaglandin Receptor
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