Product Description: Dirozalkib (Compound 4) is the inhibitor for ALK with an IC50 of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC50s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50%[1].
Formula: C27H32ClN5O4S
References: [1]Wu Y, et al., Polycyclic anaplastic lymphoma kinase inhibitor. WO2016050171
CAS Number: 1893419-37-8
Molecular Weight: 558.09
Research Area: Cancer
Target: Anaplastic lymphoma kinase (ALK)