EGFR/HDAC-IN-1

Product Description: EGFR/HDAC-IN-1 (Compound 22c2) is a potent dual inhibitor of epidermal growth factor receptor (EGFR) and histone deacetylase (HDAC) with IC50 values of 4.81 nM, 119.4 nM and 354.8 nM for EGFR, HDAC1 and HDAC3, respectively. EGFR/HDAC-IN-1 blocks the EGFR signaling pathway and affects the histone acetylation status, thereby inhibiting tumor cell proliferation. EGFR/HDAC-IN-1 is promising for research of non-small cell lung cancer (NSCLC)[1].

Formula: C22H23ClN4O5

References: [1]Yao K, et al. Synthesis and biological evaluation of novel 4-Arylaminoquinolines derivatives as EGFR/HDAC inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130214.

Molecular Weight: 458.89

Research Area: Cancer

Target: EGFR;HDAC

• SKU: MEXHY-173520-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173520-0
• Package Unit: Get quote
• Quantity Unit: STK