Product Description: EGFR-IN-155 (compound 13a) is an EGFR inhibitor with IC50 values of 0.14 nM and 0.18 nM against EGFR TK and EGFR L858R, respectively. EGFR-IN-155 inhibits tumor growth, causes a cell cycle arrest at S phase, and and induces cell apoptosis[1].
Formula: C24H22N4O3
References: [1]Saleh NS, et al. 6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies. Eur J Med Chem. 2025 Jun 5;290:117502.
Molecular Weight: 414.46
Research Area: Cancer
Target: Apoptosis;EGFR