Product Description: EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].
Applications: Neuroscience-Neuromodulation
Formula: C11H19Cl2N7O
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References: [1]Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85./[2]Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429./[3]Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.
CAS Number: 1345839-28-2
Molecular Weight: 336.22
Compound Purity: 98.31
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 130 mg/mL (ultrasonic)
Target: Autophagy;COX;Na+/H+ Exchanger (NHE);Prostaglandin Receptor;TRP Channel
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