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Encompassing Amino Acids: 22-377
Background: Fibroblast Growth Factor Receptor 2 (FGFR2) belongs to a family of transmembrane receptors with tyrosine kinase activity playing a key role in cell growth, differentiation, and tissue repair. Receptor activation by FGF ligands triggers signaling pathways that ultimately regulate cell proliferation and differentiation. FGFR2 is essential for embryonic development, particularly in the formation of the skeletal system and the development of the central nervous system. It also plays a significant role in wound healing, tissue regeneration, and tissue maintenance in adults. Dysfunction of FGFR2 is associated with a range of disorders, including craniosynostosis and certain types of cancer, therefore, FGFR2 is a candidate therapeutic target in conditions where its function is dysregulated.
Description: Human recombinant FGFR2 (Fibroblast growth factor receptor 2, also known as CD332), corresponding to amino acids 22-377, the extracellular domain. This construct contains a C-terminal Avi-Tag™ followed by a His-Tag (6xHis). The recombinant protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_000141.5
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™, His-Tag
Uniprot: P21802
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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