Product Description: GLP-1R agonist 30 is a selective and orally active GLP-1R agonist with an EC50 of 0.048 nM. GLP-1R has excellent selectivity, with EC50 greater than 20 μM for GLP-2R, GIPR, and GCPR. GLP-1R agonist significantly increases cAMP-stimulating activity while markedly reducing hERG inhibitory activities. GLP-1R agonist has preferable absorption and excellent β-arrestin pathway selectivity. GLP-1R agonist effectively improves glucose tolerance and promoted insulin secretion in B-hGLP1R knock-in mice[1].
Applications: Metabolism-sugar/lipid metabolism
Formula: C33H32F3N5O4
References: [1]Miao L, et al. Discovery of New Difluorocyclobutyl Derivatives as Effective Glucagon-Like Peptide-1 Receptor Agonists with Reduced hERG Inhibitory Activities. J Med Chem. 2025 Apr 10; 68(7):7662-7692./[2]Miao L, et al. Discovery of New Difluorocyclobutyl Derivatives as Effective Glucagon-Like Peptide-1 Receptor Agonists with Reduced hERG Inhibitory Activities. J Med Chem. 2025 Apr 10; 68(7):7662-7692.
Molecular Weight: 619.63
Research Area: Metabolic Disease; Cardiovascular Disease
Target: GLP Receptor
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