JP-153, CAS 1802937-26-3

Product Description: JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1].

Formula: C21H19NO5

References: [1]Toutounchian JJ, et al. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91(1):1-13. doi: 10.1124/mol.116.105031. Epub 2016 Nov 9. Erratum in: Mol Pharmacol. 2017 Dec;92(6):627.

CAS Number: 1802937-26-3

Molecular Weight: 365.38

Compound Purity: 99.45

Research Area: Cardiovascular Disease

Target: FAK;Src

• SKU: MEXHY-120417-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-120417-5
• Package Unit: 5 mg
• Quantity Unit: STK