NN1177 (TFA)

Product Description: NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C206H323N51O66.xC2HF3O2

References: [1]Simonsen L, et al. Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls. PLoS One. 2022 Mar 4;17(3):e0264974./[2]Monfeuga T, et al. Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients. Mol Metab. 2023 Dec 7;79:101850./[3]Säll C, et al. In vitro CYP450 enzyme down-regulation by GLP-1/glucagon co-agonist does not translate to observed drug-drug interactions in the clinic. Drug Metab Dispos. 2022 Jun 9:DMD-AR-2022-000865.

Molecular Weight: 4570.07 (free base)

Compound Purity: 98.66

Research Area: Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)

Target: Cytochrome P450;GCGR;GLP Receptor

• SKU: MEXHY-P10032A-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P10032A-1
• Package Unit: 1 mg
• Quantity Unit: STK