Ran-IN-1, CAS 2301869-11-2

Product Description: Ran-IN-1 (Compound M36) is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran (RanGDP) at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer (EOC) cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma[1].

Formula: C27H26F3NO4S

References: [1]Boudhraa Z, et al. Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer[J]. bioRxiv, 2025: 2025.03. 02.641080.

CAS Number: 2301869-11-2

Molecular Weight: 517.56

Research Area: Cancer

Target: Apoptosis;Arf Family GTPase

• SKU: MEXHY-173350-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173350-0
• Package Unit: Get quote
• Quantity Unit: STK