TYD-68

Product Description: TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways.TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359); Black: Linker (HY-W007732B); Blue: E3 ligase ligand (HY-14658); E3 ligase ligand + Linker (HY-173358))[1].

Applications: COVID-19-immunoregulation

Formula: C43H40FN11O7

References: [1]Xiong S, et al. Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model. J Med Chem. 2025 Apr 10;68(7):7560-7578.

Molecular Weight: 841.85

Research Area: Inflammation/Immunology

Target: JAK;PROTACs;STAT

• SKU: MEXHY-173357-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173357-0
• Package Unit: Get quote
• Quantity Unit: STK