Product Description: VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C19H19FN2O2
References: [1]Sengmany K, et al. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Neuropharmacology. 2017;115:60-72./[2]Rook JM, Noetzel MJ, Pouliot WA, et al. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013;73(6):501-509.
CAS Number: 1428630-85-6
Molecular Weight: 326.36
Compound Purity: 99.84
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: mGluR;PERK
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