Product Description: W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C18H28F3N2O6P
References: [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9./[2]Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1(4): 197–203./[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.
CAS Number: 909725-62-8
Molecular Weight: 456.39
Compound Purity: 98.22
Research Area: Cancer; Metabolic Disease
Solubility: DMSO : 20 mg/mL (ultrasonic;adjust pH to 3 with 1 M HCl)/Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Apoptosis;LPL Receptor
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