Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic acid, ethyl ester
Purity: ≥98%
Formula Markup: C31H39FN4O7
Formula Weight: 598.662523
CAS Number: 223537-30-2
Notes: An inhibitor of HRV 3C protease; inhibits HRV 3C protease-induced proteolysis of HRV-14 precursor polyproteins in HRV-14-infected H1HeLa cells at 2 µM; inhibits replication of 49 serotypes of HRV in HRV-infected H1HeLa cells (mean EC50 = 0.023 µM); inhibits replication of coxsackievirus 21, coxsackievirus B3, echovirus type 11, and enterovirus 70 in virus-infected MRC-5 cells (EC50s = 0.147, 0.183, 0.014, and 0.007 µM, respectively); decreases the number of HRV-2 PFUs in, and IL-8 and IL-6 secretion by, HRV-2-infected BEAS-2B cells at 10 µM; inhibits enterovirus 71-induced limb paralysis and decreases in survival, as well as reduces intestinal, lung, brain stem, and cardiac muscle viral loads, in enterovirus-71-infected neonatal mice at 0.1 mg/kg per day
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