SB-505124 (hydrochloride), CAS 356559-13-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine, monohydrochloride

Purity: ≥98%

Formula Markup: C20H21N3O2 / HCl

Formula Weight: 371.9

CAS Number: 356559-13-2

Notes: An ALK5 and ALK4 inhibitor (IC50s = 47 and 129 nM, respectively); selective for ALK5 and ALK4 over a panel of 27 kinases at 10 µM; inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 µM; inhibits TGF-β-induced but not TNF-α-induced apoptosis in Fao cells at 1 µM; decreases IOP and subconjunctival immune cell infiltration in a rabbit model of trabeculectomy at 5 mg/eye

• SKU: CAY42056-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42056-1
• Package Unit: 1 mg
• Quantity Unit: STK