1G244, CAS 847928-32-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2S-amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione

Purity: ≥95%

Formula Markup: C29H30F2N4O2

Formula Weight: 504.6

CAS Number: 847928-32-9

Notes: A DPP-8 and DPP-9 inhibitor (IC50s = 14 and 53 nM, respectively); selective for DPP-8 and DPP-9 over DPP-4, DPP-2, and FAP (IC50s = >100 µM for all); inhibits the differentiation of 3T3-L1 cells into adipocytes at 20 µM; induces caspase-1-dependent pyroptosis in RAW 264.7 macrophages at 10 µM; decreases atherosclerotic lesion area and M1-like macrophage plaque infiltration in apoE-/- mice in a model of atherosclerosis induced by a high-fat diet

• SKU: CAY18306-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18306-50
• Package Unit: 50 mg
• Quantity Unit: STK