AG-9, CAS 2826-26-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-[(4-methoxyphenyl)methylene]-propanedinitrile

Purity: ≥95%

Formula Markup: C11H8N2O

Formula Weight: 184.2

CAS Number: 2826-26-8

Notes: An immunomodulatory agent; selectively inhibits IL-12-induced tyrosine phosphorylation of TYK2 and STAT3 over JAK2 in primary mouse concanavalin A-activated T cells at 10 µM; does not inhibit EGFR (IC50 = >1,250 µM), unlike most tyrphostins, and has commonly been used as an inactive control for tyrphostin tyrosine kinase inhibitory activity; inhibits CD40L-induced IL-12 production and NF-κB translocation in primary mouse macrophages; reduces the development and severity of EAE in mice; inhibits GABA-induced activation of wild-type GABAA receptors and GABAAY365F/Y367F receptors expressed in Xenopus oocytes at 200 µM

• SKU: CAY42420-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42420-5
• Package Unit: 5 mg
• Quantity Unit: STK