Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-benzenemethanaminium, dichloride
Purity: ≥95%
Formula Markup: C28H42Cl2N4O2 / 2Cl
Formula Weight: 608.5
CAS Number: 115-79-7
Notes: Ambenonium is an inhibitor of acetylcholinesterase (AChE; IC50 = 0.7 nM).{69861} It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 6.82 µM). Ambenonium (10 µM) increases the secretion of amyloid precursor protein (APP) in primary rat basal forebrain cells.{69862} It induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats when administered intra-arterially at a dose of 5 µg/animal.{69863} Ambenonium (3 µg/animal) inhibits paralysis induced by the neuromuscular blocking agents tubocurarine or decamethonium (Item No. 24907) in anesthetized cats.{69864} Formulations containing ambenonium have previously been used in the treatment of myasthenia gravis.
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