AMG 2850, CAS 1470018-52-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5,8R-dihydro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-8-[4-(trifluoromethyl)phenyl]-1,7-naphthyridine-7(6H)-carboxamide

Purity: ≥98%

Formula Markup: C19H17F6N3O

Formula Weight: 417.355419

CAS Number: 1470018-52-0

Notes: A TRPM8 antagonist; inhibits menthol- or cold-induced intracellular calcium release in CHO cells expressing rat TRPM8 (IC50s = 7.3 and 150 nM, respectively); selective for TRPM8 over TRPA1, TRPV1, TRPV3, and TRPV4 (IC50s = >20, >10, >10, and >10 µM, respectively); decreases body temperature in rats and mice at 100 mg/kg; inhibits icilin-induced wet-dog shakes in rats at 10 mg/kg

• SKU: CAY42906-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42906-5
• Package Unit: 5 mg
• Quantity Unit: STK