Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis[5-[[(2-hydroxyethyl)amino]methyl]-2-pyridinecarboxamide
Purity: ≥98%
Formula Markup: C32H36N6O4
Formula Weight: 568.66628
CAS Number: 2368182-63-0
Notes: A PD-1/PD-L1 interaction inhibitor (IC50 = 400 pM in an HTRF assay); inhibits the PD-1/PD-L1 interaction in a cell-based NFAT reporter assay (IC50 = 17 nM); decreases cell surface levels of PD-L1 in primary human dendritic cells and B cells; reduces CMV antigen-induced IFN-γ production in a CMV recall assay using PBMCs isolated from CMV seropositive patients (IC50 = 3 nM); induces T cell proliferation and IFN-γ production in PBMCs isolated from patients with chronic HBV infection at 500 nM in the presence of HBV peptides; reduces tumor volume and PD-L1 levels in CD45- tumor cells in a humanized MC-38 murine model of colon cancer at 10 mg/kg
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