ART558, CAS 2603528-97-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-2-pyrrolidinecarboxamide

Purity: ≥98%

Formula Markup: C21H21F3N4O2

Formula Weight: 418.412409

CAS Number: 2603528-97-6

Notes: A DNA polymerase θ inhibitor (IC50 = 7.9 nM for Polθ polymerase activity); selective for the polymerase activity of Polθ over its ATPase activity (IC50 = >12 µM); inhibits the repair of DNA double-strand breaks via TMEJ, but not NHEJ, in a reporter assay using an extrachromosomal DNA substrate at 0.1, 0.3, and 1 µM; induces synthetic lethality in RPE1 cells lacking BRCA1 and DLD-1 cells lacking BRCA2; reduces tumor growth in a 3D organoid culture model using cells derived from patients with BRCA1-low, 53BP1-low prostate cancer

• SKU: CAY42324-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42324-50
• Package Unit: 50 mg
• Quantity Unit: STK