ART558 (GMP), CAS 2603528-97-6

Product Description: ART558 (GMP) is ART558 (HY-141520) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ART558 is a potent, selective and allosteric DNA polymerase theta (Polθ) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer[1].

Formula: C21H21F3N4O2

References: [1]Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636.

CAS Number: 2603528-97-6

Molecular Weight: 418.41

Research Area: Cancer

Target: DNA/RNA Synthesis

• SKU: MEXHY-141520G-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-141520G-0
• Package Unit: Get quote
• Quantity Unit: STK