Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-methyl-N-[4-(methylsulfonyl)phenyl]-thieno[2,3-d]pyrimidin-4-amine
Purity: ≥98%
Formula Markup: C14H13N3O2S2
Formula Weight: 319.4
CAS Number: 2924824-56-4
Notes: ARUK2001607 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = 0.079 µM for PI5P4Kγ+, a construct with mutations conferring increased functional activity).{68883} It selectively binds to PI5P4Kγ (Kd = 7.1 nM) over 22 other lipid kinases but does bind to phosphatidylinositol 4-phosphate 5-kinase type-1 γ (PIP5K1C; Kd = 230 nM). ARUK2001607 is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >15.8 and >25.1 µM, respectively). It is also selective for PI5P4Kγ over 138 other kinases in a kinase panel and a variety of receptors, enzymes, and ion channels in a safety panel at 10 µM but does inhibit Aurora B kinase and CDC-like kinase 2 (CLK2) by 31 and 37% and dopamine uptake by 59% at 10 µM.
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