ATC 0175, CAS 510733-97-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[cis-4-[[4-(dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluoro-benzamide, monohydrochloride

Purity: ≥95%

Formula Markup: C23H25F2N5O / HCl

Formula Weight: 461.935146

CAS Number: 510733-97-8

Notes: An MC1R antagonist (IC50 = 7.23 nM); selective for MC1R over MC2R (IC50 = >10,000 nM) but does antagonize 5-HT2B and 5-HT1A receptors (IC50s = 9.66 and 16.9 nM, respectively); inhibits MCH-induced [35S]GTPγS binding and calcium influx in HEK293 cells expressing human MC1R at 3 nM; reduces stress-induced decreases in the time spent in the open arms of the elevated plus maze in mice at 1, 3, and 10 mg/kg; decreases immobility time in the forced swim test in mice

• SKU: CAY42376-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42376-5
• Package Unit: 5 mg
• Quantity Unit: STK