Shelf life (days): 1460.0
Formulation: A solid
Formal Name: [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluoro-sulfur
Purity: ≥98%
Formula Markup: C26H19F5N6OS
Formula Weight: 558.5
CAS Number: 1448316-08-2
Notes: BAY-826 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2; IC50 = 0.5 nM).{72444} It inhibits Tie2 autophosphorylation in human umbilical vein endothelial cells (HUVECs; EC50 = 1.3 nM).{72445} BAY-826 (0.1 or 1 µM), in combination with radiation, reduces colony formation in a colony formation assay using SMA-497, SMA-540, SMA-560, and GL261 mouse glioma cells. In vivo, BAY 826 (100 mg/kg per day), in combination with radiation, decreases tumor volume and vascularization, as well as increases the number of CD45+ T cell tumor infiltrates and animal survival in an SMA-560 murine glioma model.
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