BLU-945, CAS 2660250-10-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[2-[(3S,4R)-3-fluoro-4-methoxy-1-piperidinyl]-4-pyrimidinyl]-5-(1-methylethyl)-8-[(2R,3S)-2-methyl-3-[(methylsulfonyl)methyl]-1-azetidinyl]-3-isoquinolinamine

Purity: ≥98%

Formula Markup: C28H37FN6O3S

Formula Weight: 556.701403

CAS Number: 2660250-10-0

Notes: An inhibitor of mutant EGFR (IC50s = 0.4 and 0.5 nM for EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively); selective for these mutants over wild-type EGFR (IC50 = 683 nM) and a panel of >400 kinases at 3 µM; induces tumor regression in a mouse xenograft model using H1975 NSCLC cells, which express EGFRL858R/T790M; inhibits tumor growth in an osimertinib-resistant PDX mouse model of NSCLC using tumors harboring EGFRT790M/C797S with an exon 19 deletion

• SKU: CAY43015-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43015-5
• Package Unit: 5 mg
• Quantity Unit: STK