Shelf life (days): 365.0
Formulation: A solution in methyl acetate
Formal Name: 2a,3ß-dihydroxy-urs-12-en-28-oic acid, propyl ester
Purity: ≥98%
Formula Markup: C33H54O4
Formula Weight: 514.791
CAS Number: 958237-73-5
Notes: A synthetic pentacyclic triterpenoid; has been used in the generation of LNPs for the delivery of mRNA and siRNA in vitro and in vivo; inhibits glycogen phosphorylase (IC50 = 82.5 µM for the rabbit muscle enzyme); LNPs containing corosolic acid β and encapsulating an mRNA reporter show greater transfection efficiency than those containing cholesterol in 4T1, B16/F10, and HeLa cells; corosolic acid β-containing LNPs selectively accumulate in tumors and do not accumulate in the liver compared with cholesterol-containing LNPs, which accumulate in both, following intratumoral injection; LNPs containing corosolic acid β and encapsulating siRNA targeting mRNA encoding Bcl-2 decrease tumor volume and lung metastasis and increase survival in a 4T1 murine mammary carcinoma model
English
Deutsch
