DCZ0415, CAS 2242470-43-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4,4a,5,5a,6,6a-hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione

Purity: ≥98%

Formula Markup: C23H20N2O2

Formula Weight: 356.41718

CAS Number: 2242470-43-3

Notes: A TRIP13 inhibitor; binds to TRIP13 (Kd = 2.42 µM) and reduces NHEJ repair of DNA in a reporter assay; impairs DNA repair in ARP-1 and NCI H929 multiple myeloma cells at 10 and 20 µM; reduces the growth of a variety of multiple myeloma cells, including RPMI-8226, ARP-1, and ARK cells (IC50s = 7.4, 5.12, and 3.25 µM, respectively) and induces apoptosis in ARP-1 cells; induces intratumoral apoptosis and impairs intratumoral DNA repair, reduces tumor volume, and increases survival in an NCI H929 mouse xenograft model at 50 mg/kg per day

• SKU: CAY42513-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42513-1
• Package Unit: 1 mg
• Quantity Unit: STK