DMX-5084, CAS 2306178-56-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

Purity: ≥98%

Formula Markup: C21H19N3O3

Formula Weight: 361.39398

CAS Number: 2306178-56-1

Notes: A MAP4K4 inhibitor (IC50 = 3 nM); selective for MAP4K4 over a panel of 141 kinases at 1 µM but does inhibit MAP4K6 and TNIK (IC50s = 6.61 and 10.96 nM, respectively); prevents hydrogen peroxide-induced decreases in viability in vCor.4U cells (EC50 = 3.16 nM); inhibits menadione-induced decreases in the OCR and ECAR in vCor.4U cells at 3 or 10 µM; prevents menadione-induced decreases in the number of beats per minute and force of contraction in a 3D hEHT model using vCor.4U cells; reduces infarct size in a mouse model of ischemia-reperfusion injury induced by LAD coronary artery occlusion at 50 mg/kg

• SKU: CAY42334-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42334-5
• Package Unit: 5 mg
• Quantity Unit: STK