DNL343, CAS 2278265-85-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-(4-chlorophenoxy)-N-[3-[5-[cis-3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]bicyclo[1.1.1]pent-1-yl]-acetamide

Purity: ≥98%

Formula Markup: C20H19ClF3N3O4

Formula Weight: 457.8

CAS Number: 2278265-85-1

Notes: DNL343 is an activator of eukaryotic translation initiation factor 2B (eIF2B; IC50 = 9.8 nM in a reporter assay) and a derivative of 2BAct (Item No. 37788).{49932} It inhibits sodium arsenite-induced formation of stress granules positive for TAR DNA-binding protein 43 (TDP-43) in an in vitro model of amyotrophic lateral sclerosis (ALS) using H4 cells (IC50 = 12.46 nM). DNL343 (50 mg/kg) decreases the expression of integrated stress response (ISR) genes in Eif2b5R191H mutant mice in a model of neurodegeneration.

• SKU: CAY41674-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41674-10
• Package Unit: 10 mg
• Quantity Unit: STK