GFB-8438, CAS 2304549-73-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-chloro-5-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]-1-piperazinyl]-3(2H)-pyridazinone

Purity: ≥98%

Formula Markup: C16H14ClF3N4O2

Formula Weight: 386.759209

CAS Number: 2304549-73-1

Notes: A TRPC5 inhibitor (IC50 = 0.18 µM); selective for TRPC5 over TRPC6 and Nav1.5 (IC50s = >30 µM for both) and a panel of 100 receptors and kinases at 10 µM but does inhibit TRPC4 (IC50 = 0.29 µM); decreases urinary excretion of total protein and albumin in a rat model of high salt- and unilateral nephrectomy-induced renal hypertension at 30 mg/kg per day

• SKU: CAY43035-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43035-100
• Package Unit: 100 mg
• Quantity Unit: STK