HIF-2α Translation Inhibitor 76, CAS 882268-69-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[[cyano(methylsulfonyl)methylene]hydrazinyl]-2-thiophenecarboxylic acid, methyl ester

Purity: ≥98%

Formula Markup: C9H9N3O4S2

Formula Weight: 287.31758

CAS Number: 882268-69-1

Notes: A HIF-2α translation inhibitor; inhibits constitutive gene expression in an HRE reporter assay using VHL-deficient 786-O cells (IC50 = 5 µM); reduces the translation of nascent HIF-2α mRNA in 786-O cells; inhibits DMOG-induced erythrocytosis and angiogenesis in zebrafish at 10 nM; increases survival and right ventricle contractility and inhibits right ventricle hypertrophy in a rat model of monocrotaline-induced pulmonary arterial hypertension

• SKU: CAY42446-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42446-5
• Package Unit: 5 mg
• Quantity Unit: STK