HS-276, CAS 2767422-72-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N1-[6-(1-piperidinylmethyl)-1-propyl-1H-benzimidazol-2-yl]-1,3-benzenedicarboxamide

Purity: ≥98%

Formula Markup: C24H29N5O2

Formula Weight: 419.529

CAS Number: 2767422-72-8

Notes: A TAK1 inhibitor (IC50 = 8.25 nM); selective for TAK1 over a panel of 137 other kinases at 10 µM but does inhibit Clk2, HK, and ULK2 (IC50s = 29, 33, and 63 nM, respectively); inhibits LPS-induced increases in secretion of TNF, IL-6, and IL-1β from PMA-differentiated THP-1 macrophages (IC50s = 138, 201, and 234 nM, respectively); inhibits collagen-induced increases in pannus formation, cartilage damage, bone resorption, and periosteal bone formation in a mouse model of rheumatoid arthritis at 50 mg/kg twice per day

• SKU: CAY43026-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43026-25
• Package Unit: 25 mg
• Quantity Unit: STK