JH-X-119-01, CAS 2227368-54-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-2-pyridinecarboxamide

Purity: ≥95%

Formula Markup: C25H20N6O3

Formula Weight: 452.474

CAS Number: 2227368-54-7

Notes: An IRAK1 inhibitor (IC50 = 9 nM); selective for IRAK1 over IRAK4 (IC50 = >10,000 nM); cytotoxic against a panel of mutant MyD88-expressing WM, ABC subtype DLBCL, and lymphoma cells (EC50s = 0.59-9.72 µM); has a synergistic cytotoxic effect in MyD88-mutant-expressing BCWM.1 WM and TMD8 ABC DLBCL cells when used in combination with ibrutinib; reduces lung injury and increases survival in a mouse model of LPS-induced sepsis at 5 and 10 mg/kg

• SKU: CAY43041-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43041-50
• Package Unit: 50 mg
• Quantity Unit: STK