JNJ-47117096 (trifluoroacetate salt)

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-benzamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C21H22N4O2 / CF3COOH

Formula Weight: 476.4

Notes: A MELK inhibitor (IC50 = 37 nM); selective for MELK over CAMKIIδ, MNK2, CAMKIIγ, and MLCK (IC50s = 810, 760, 1,000, and 1,000 nM, respectively) but does inhibit FLT3 (IC50 = 18 nM); inhibits MELK autophosphorylation (IC50 = 0.52 µM) and MELK proteasome-dependent degradation in MCF-7 cells; induces cellular senescence and the ATM-mediated DNA damage response in MCF-7 cells

• SKU: CAY41605-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41605-1
• Package Unit: 1 mg
• Quantity Unit: STK