JPH203, CAS 1037592-40-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine

Purity: ≥98%

Formula Markup: C23H19Cl2N3O4

Formula Weight: 472.32018

CAS Number: 1037592-40-7

Notes: An inhibitor of LAT1 (IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter); selective for LAT1 over LAT2 (IC50 = >10 μM); inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively); induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and PARP in YD-38 oral cancer cells at 3 mM; reduces tumor growth in an HT-29 mouse xenograft model at 6.3, 12.5, and 25 mg/kg

• SKU: CAY29715-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29715-25
• Package Unit: 25 mg
• Quantity Unit: STK