Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1S)-2-[[(3-bromo-4,5-dihydro-5-isoxazolyl)methyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]-carbamic acid, phenylmethyl ester
Purity: ≥98%
Formula Markup: C21H22BrN3O5
Formula Weight: 476.3206
CAS Number: 744198-19-4
Notes: An inhibitor of TG2 (Ki = 0.068 mM); reduces radiation-induced increases in TGM2 expression in wild-type H1299 and H1299/M175H-p53 cells at 3.91 µM; sensitizes wild-type H1299 and H1299/M175H-p53 cells to radiation and induces cell cycle arrest at the G0/G1 and G2/M phases, respectively; inhibits fibronectin remodeling in U87MG glioblastoma cells at 1 mM; sensitizes tumors to N,N’-bis(2-chloroethyl)-N-nitrosourea and increases survival in an orthotopic mouse model of DBT-FG glioblastoma when administered in combination with N,N’-bis(2-chloroethyl)-N-nitrosourea at 50 mg/kg; reverses warfarin-induced arterial calcification in rats; prevents relapse in a rat model of EAE
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