Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (R)-N-[2-[acetyl[(2-methoxyphenyl)methyl]amino]-1-(1H-indol-3-ylmethyl)ethyl]-[1,4'-bipiperidine]-1'-acetamide, dihydrochloride
Purity: ≥98%
Formula Markup: C33H45N5O3 / 2HCl
Formula Weight: 632.7
CAS Number: 170508-05-1
Notes: An NK1 receptor antagonist (Ki = 0.15 nM); inhibits Ac-[Arg6,Sar9,Met(O2)11]-substance P6-11-induced increases in tail biting and scratching in mice at 1, 5, or 10 mg/kg; inhibits late-phase formalin-induced increases in paw licking in mice at 10 mg/kg; reduces corneal opacity and neovascularization and decreases leukocyte infiltration in a mouse model of alkali burn-induced corneal damage when topically applied at 6.4 mg/ml six times per day