MDI-114215

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(cyclopropylmethyl)-N-(4-((2-hydroxyethyl)amino)benzyl)-4-(N-phenylsulfamoyl)benzamide

Purity: ≥97%

Formula Markup: C26H29N3O4S

Formula Weight: 479.595

Notes: An allosteric inhibitor of LIMK1 and LIMK2 (IC50s = 19.95 and 26.92 nM, respectively); selective for LIMK1 and LIMK2 in a panel of 468 kinases but does bind to Cdk7, MKK7, VRK2, and phosphorylated Abl1 at 300 nM; selective for LIMK1 and LIMK2 in a panel of 44 receptors, ion channels, transporters, and enzymes but does bind to CB1 receptor at 10 µM; reduces PAK1-phosphorylated cofilin levels in SH-SY5Y cells (IC50 = 50.12 nM); enhances LTP in hippocampal slices from Fmr1 knockout mice at 3 µM

• SKU: CAY42919-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42919-1
• Package Unit: 1 mg
• Quantity Unit: STK